منابع مشابه
The planar polarity pathway
to the brain and receive high-order commands and inputs from it. That is, much of the planning, computation and execution of stereotypic arm movements are conducted within the arm neural system itself. Accordingly, natural-looking arm extension movements can be generated in amputated arms. This organization may be an optimal solution for the motor control of highly redundant flexible appendages...
متن کاملRab6 and the secretory pathway affect oocyte polarity in Drosophila.
The Drosophila oocyte is a highly polarized cell. Secretion occurs towards restricted neighboring cells and asymmetric transport controls the localization of several mRNAs to distinct cortical compartments. Here, we describe a role for the Drosophila ortholog of the Rab6 GTPase, Drab6, in establishing cell polarity during oogenesis. We found that Drab6 localizes to Golgi and Golgi-derived membr...
متن کاملThe Hippo pathway and apico-basal cell polarity.
The establishment and maintenance of apico-basal cell polarity is a pre-requisite for the formation of a functioning epithelial tissue. Many lines of evidence suggest that cell polarity perturbations favour cancer formation, even though the mechanistic basis for this link remains unclear. Studies in Drosophila have uncovered complex interactions between the conserved Hpo (Hippo) tumour suppress...
متن کاملA FOXO-Pak1 transcriptional pathway controls neuronal polarity.
Neuronal polarity is essential for normal brain development and function. However, cell-intrinsic mechanisms that govern the establishment of neuronal polarity remain to be identified. Here, we report that knockdown of endogenous FOXO proteins in hippocampal and cerebellar granule neurons, including in the rat cerebellar cortex in vivo, reveals a requirement for the FOXO transcription factors i...
متن کاملPlanar Cell Polarity Signaling Pathway in Congenital Heart Diseases
Congenital heart disease (CHD) is a common cardiac disorder in humans. Despite many advances in the understanding of CHD and the identification of many associated genes, the fundamental etiology for the majority of cases remains unclear. The planar cell polarity (PCP) signaling pathway, responsible for tissue polarity in Drosophila and gastrulation movements and cardiogenesis in vertebrates, ha...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2010
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2010.12.025